Molecular and clinical evaluation of a patient hemizygous for TIGR/MYOC
JL Wiggs, D Vollrath - Archives of ophthalmology, 2001 - jamanetwork.com
Objective To determine if a patient with an interstitial deletion of chromosome 1 is
hemizygous for theTIGR/MYOCgene and if that patient has glaucoma. Methods A patient
with an interstitial deletion of chromosome 1 was clinically examined for evidence of
glaucoma. DNA samples from the patient and her family were used for molecular studies to
determine the boundaries of the chromosome 1 deletion using polymorphic markers located
on chromosome 1q21 to 1q24. Additional markers located in the vicinity of …
hemizygous for theTIGR/MYOCgene and if that patient has glaucoma. Methods A patient
with an interstitial deletion of chromosome 1 was clinically examined for evidence of
glaucoma. DNA samples from the patient and her family were used for molecular studies to
determine the boundaries of the chromosome 1 deletion using polymorphic markers located
on chromosome 1q21 to 1q24. Additional markers located in the vicinity of …