Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion
J Ruiz-Ederra, AS Verkman - Experimental eye research, 2006 - Elsevier
We have developed an inducible mouse model of glaucoma based on episcleral vein
cauterization (EVC). Intraocular pressure (IOP) elevation in adult mice was produced by
cauterizing three episcleral veins. Serial IOP measurements were done by induction-impact
tonometry. IOP was significantly elevated by 104±20% in 20 out of 23 mice (87%) within the
first day after EVC, and remained elevated for 4 weeks, with mean IOP 94% higher in EVC-
treated vs. contralateral control eyes. Aqueous outflow blockade was verified from the IOP …
cauterization (EVC). Intraocular pressure (IOP) elevation in adult mice was produced by
cauterizing three episcleral veins. Serial IOP measurements were done by induction-impact
tonometry. IOP was significantly elevated by 104±20% in 20 out of 23 mice (87%) within the
first day after EVC, and remained elevated for 4 weeks, with mean IOP 94% higher in EVC-
treated vs. contralateral control eyes. Aqueous outflow blockade was verified from the IOP …