[HTML][HTML] Receptor activator of NF-κB and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in …
P Collin-Osdoby, L Rothe, F Anderson… - Journal of Biological …, 2001 - ASBMB
The receptor activator of NF-κB (RANKL) is the essential signal required for full osteoclast
(OC) development, activation, and survival. RANKL is highly expressed in areas of
trabecular bone remodeling and inflammatory bone loss, is increased on marrow stromal
cells or osteoblasts by osteotropic hormones or cytokines, and is neutralized by
osteoprotegerin (OPG), a soluble decoy receptor also crucial for preventing arterial
calcification. Vascular endothelial cells (VEC) are critically involved in bone development …
(OC) development, activation, and survival. RANKL is highly expressed in areas of
trabecular bone remodeling and inflammatory bone loss, is increased on marrow stromal
cells or osteoblasts by osteotropic hormones or cytokines, and is neutralized by
osteoprotegerin (OPG), a soluble decoy receptor also crucial for preventing arterial
calcification. Vascular endothelial cells (VEC) are critically involved in bone development …