Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on β-catenin in mouse hippocampus
O Kaidanovich-Beilin, A Milman, A Weizman… - Biological …, 2004 - Elsevier
BACKGROUND: Inhibition of glycogen synthase kinase-3 (GSK-3) is thought to be a key
feature in the therapeutic mechanism of several mood stabilizers; however, the role of GSK-
3 in depressive behavior has not been determined. In these studies, we evaluated the
antidepressive effect of L803-mts, a novel GSK-3 peptide inhibitor, in an animal model of
depression, the mouse forced swimming test (FST). METHODS: Animals were
intracerebroventricularly injected with L803-mts or with respective control peptide (cp) 1 …
feature in the therapeutic mechanism of several mood stabilizers; however, the role of GSK-
3 in depressive behavior has not been determined. In these studies, we evaluated the
antidepressive effect of L803-mts, a novel GSK-3 peptide inhibitor, in an animal model of
depression, the mouse forced swimming test (FST). METHODS: Animals were
intracerebroventricularly injected with L803-mts or with respective control peptide (cp) 1 …