Rapid loss of trabecular bone (as after menopause) occurs by complete removal of some
structural elements, leaving those that remain more widely separated and less well
connected. The most likely cellular mechanism is an increase in the number of resorption
cavities deep enough to lead to focal perforation of trabecular plates, either as a non-specific
consequence of increased remodeling activation, or as a specific consequence (direct or
indirect) of estrogen deficiency. Disruption of the connections between structural elements …