[HTML][HTML] Modifying apolipoprotein AI by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway
Dysfunctional high density lipoprotein (HDL) is implicated in the pathogenesis of
cardiovascular disease, but the underlying pathways remain poorly understood. One
potential mechanism involves covalent modification by reactive carbonyls of apolipoprotein
AI (apoA-I), the major HDL protein. We therefore determined whether carbonyls resulting
from lipid peroxidation (malondialdehyde (MDA) and hydroxynonenal) or carbohydrate
oxidation (glycolaldehyde, glyoxal, and methylglyoxal) covalently modify lipid-free apoA-I …
cardiovascular disease, but the underlying pathways remain poorly understood. One
potential mechanism involves covalent modification by reactive carbonyls of apolipoprotein
AI (apoA-I), the major HDL protein. We therefore determined whether carbonyls resulting
from lipid peroxidation (malondialdehyde (MDA) and hydroxynonenal) or carbohydrate
oxidation (glycolaldehyde, glyoxal, and methylglyoxal) covalently modify lipid-free apoA-I …