Cellular senescence and organismal aging

JC Jeyapalan, JM Sedivy - Mechanisms of ageing and development, 2008 - Elsevier
Cellular senescence, first observed and defined using in vitro cell culture studies, is an
irreversible cell cycle arrest which can be triggered by a variety of factors. Emerging
evidence suggests that cellular senescence acts as an in vivo tumor suppression
mechanism by limiting aberrant proliferation. It has also been postulated that cellular
senescence can occur independently of cancer and contribute to the physiological
processes of normal organismal aging. Recent data have demonstrated the in vivo …