Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages
L Noureddine, R Azzam, G Nemer, J Bielawski… - Prostaglandins & other …, 2008 - Elsevier
Ceramide has been implicated in regulatory processes vital for cell survival under different
stressors, most notably hypoxia. Little has been done to investigate the contributions of the
different ceramide species to the regulation of cell survival. This study aims to highlight the
patterns of variation in total ceramide and its species in the growing and hypoxic mouse
heart. Mus musculus mice were placed in a hypoxic environment at birth. Control animals
remained in room air. The hearts were extracted at different time points: 1 day, 1 week, 4 …
stressors, most notably hypoxia. Little has been done to investigate the contributions of the
different ceramide species to the regulation of cell survival. This study aims to highlight the
patterns of variation in total ceramide and its species in the growing and hypoxic mouse
heart. Mus musculus mice were placed in a hypoxic environment at birth. Control animals
remained in room air. The hearts were extracted at different time points: 1 day, 1 week, 4 …