[HTML][HTML] Immunobiology of chronic lung allograft dysfunction: new insights from the bench and beyond
RA Shilling, DS Wilkes - American Journal of Transplantation, 2009 - Elsevier
The first successful human lung transplants were performed in the 1980s. Since that time
lung transplantation has been a therapeutic modality for end-stage pulmonary diseases.
However, chronic rejection, known as obliterative bronchiolitis (OB)/bronchiolitis obliterans
syndrome (BOS), is the key reason why the 5-year survival is only 50%, which is significantly
worse than most other solid organ transplants. Recent studies have provided exciting
advances that are beginning to be translated into findings in humans. This review will …
lung transplantation has been a therapeutic modality for end-stage pulmonary diseases.
However, chronic rejection, known as obliterative bronchiolitis (OB)/bronchiolitis obliterans
syndrome (BOS), is the key reason why the 5-year survival is only 50%, which is significantly
worse than most other solid organ transplants. Recent studies have provided exciting
advances that are beginning to be translated into findings in humans. This review will …