Histologic classification of idiopathic chronic interstitial pneumonias

S Dacic, SA Yousem - American journal of respiratory cell and …, 2003 - search.proquest.com
S Dacic, SA Yousem
American journal of respiratory cell and molecular biology, 2003search.proquest.com
The diagnosis and management of idiopathic interstitial pneumonia (IIP) have challenged
physicians since their description more than a century ago. Significant progress in the
understanding of interstitial lung diseases was made in the mid-1960s with recognition of
collagen vascular diseases (CVD), drugs, and occupational exposures as potential causes.
However, a large group of entities still remained idiopathic, and in 1968 Liebow and
Carrington were first to classify chronic IIPs into the following five histopathologic subgroups …
The diagnosis and management of idiopathic interstitial pneumonia (IIP) have challenged physicians since their description more than a century ago. Significant progress in the understanding of interstitial lung diseases was made in the mid-1960s with recognition of collagen vascular diseases (CVD), drugs, and occupational exposures as potential causes. However, a large group of entities still remained idiopathic, and in 1968 Liebow and Carrington were first to classify chronic IIPs into the following five histopathologic subgroups: usual interstitial pneumonia (UIP), bronchiolitis interstitial pneumonia (BIP), desquamative interstitial pneumonia (DIP), giant cell interstitial pneumonia (GIP), and lymphoid interstitial pneumonia (LIP)(1).
In the ensuing twenty years, new entities were described and the original IIPs studied in greater depth. The results were then codified in the classification schema described in 1998 by Katzenstein and Myers (2). Their classification scheme recognized five entities: usual interstitial pneumonia (UIP), desquamative interstitial pneumonia (DIP), respiratory bronchiolitis-associated interstitial lung disease (RBILD), nonspecific interstitial pneumonia (NSIP), and acute interstitial lung disease (AIP)(former Hamman-Rich syndrome).
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