Math1-driven GFP expression in the developing nervous system of transgenic mice

EA Lumpkin, T Collisson, P Parab… - Gene Expression …, 2003 - Elsevier
Math1 is a bHLH transcription factor expressed in neural progenitor cells in multiple regions
of the nervous system. Previously we identified a Math1 enhancer that directs expression of
reporter genes in a Math1 specific pattern [Development 127 (2000) 1185]. We have used a
portion of this enhancer to drive expression of a nuclear GFP reporter in the Math1 lineage
in transgenic mice. In this transgenic mouse strain, GFP is expressed in Math1 domains in
the (1) developing spinal cord in progenitors to dI1 dorsal interneurons,(2) granule-cell …