New molecular targets for the treatment of neutrophilic diseases

PJ Barnes - Journal of Allergy and Clinical Immunology, 2007 - Elsevier
Increased neutrophils are a feature of airway inflammation in patients with chronic
obstructive pulmonary disease and in some patients with asthma, particularly patients with
more severe disease, during exacerbations and with cigarette smoking. Because
neutrophilic inflammation may be detrimental, there are several new approaches to
inhibiting neutrophilic inflammation. Neutrophilic inflammation is resistant or poorly
responsive to corticosteroids, so different anti-inflammatory approaches are needed …