[HTML][HTML] Mitochondrial reactive oxygen species: a common pathway for PAR1-and PAR2-mediated tissue factor induction in human endothelial cells
Summary Background: Protease-activated receptors (PARs) comprise a family of G-protein-
coupled receptors with a unique proteolytic activation mechanism. PARs regulate a broad
range of cellular functions and are involved in the pathogenesis of inflammatory disorders.
Moreover, PAR1 and PAR2 activation in the endothelium shifts it toward a prothrombotic
condition. Objectives: To assess the relevance of intracellular reactive oxygen species
(ROS) in the signaling events underlying tissue factor (TF) expression elicited by PAR1 and …
coupled receptors with a unique proteolytic activation mechanism. PARs regulate a broad
range of cellular functions and are involved in the pathogenesis of inflammatory disorders.
Moreover, PAR1 and PAR2 activation in the endothelium shifts it toward a prothrombotic
condition. Objectives: To assess the relevance of intracellular reactive oxygen species
(ROS) in the signaling events underlying tissue factor (TF) expression elicited by PAR1 and …
