[HTML][HTML] Reduced display of tumor necrosis factor receptor I at the host cell surface supports infection with Chlamydia trachomatis
N Paland, L Bohme, RK Gurumurthy, A Mäurer… - Journal of biological …, 2008 - ASBMB
The obligate intracellular human pathogenic bacterium Chlamydia trachomatis has evolved
multiple mechanisms to circumvent the host immune system. Infected cells exhibit a
profound resistance to the induction of apoptosis and down-regulate the expression of major
histocompatibility complex class I and class II molecules to evade the cytotoxic effect of
effector immune cells. Here we demonstrate the down-regulation of tumor necrosis factor
receptor 1 (TNFR1) on the surface of infected cells. Interestingly, other members of the TNFR …
multiple mechanisms to circumvent the host immune system. Infected cells exhibit a
profound resistance to the induction of apoptosis and down-regulate the expression of major
histocompatibility complex class I and class II molecules to evade the cytotoxic effect of
effector immune cells. Here we demonstrate the down-regulation of tumor necrosis factor
receptor 1 (TNFR1) on the surface of infected cells. Interestingly, other members of the TNFR …