[HTML][HTML] Membrane-anchored CD40 is processed by the tumor necrosis factor-α-converting Enzyme: implications for CD40 signaling
C Contin, V Pitard, T Itai, S Nagata, JF Moreau… - Journal of Biological …, 2003 - ASBMB
The soluble form of CD40 (sCD40), which co-exists with the membrane-anchored form
(mCD40), is a natural antagonist of mCD40/CD154 interaction. However, the mechanism
leading to the production of sCD40 has never been investigated. Here, we show that the
engagement of mCD40 on the surface of B lymphocytes by anti-CD40 antibody led to
enhanced sCD40 release associated with decreased amounts of mCD40. This sCD40
production was not affected by vesicular traffic inhibitors but was completely blocked by a …
(mCD40), is a natural antagonist of mCD40/CD154 interaction. However, the mechanism
leading to the production of sCD40 has never been investigated. Here, we show that the
engagement of mCD40 on the surface of B lymphocytes by anti-CD40 antibody led to
enhanced sCD40 release associated with decreased amounts of mCD40. This sCD40
production was not affected by vesicular traffic inhibitors but was completely blocked by a …