[HTML][HTML] Differential activation of NF-κB subunits in dendritic cells in response to Gram-negative bacteria and to lipopolysaccharide
S Hofer, M Rescigno, F Granucci, S Citterio… - Microbes and …, 2001 - Elsevier
Dendritic cell (DC) maturation is essential for the initiation of T-dependent immune
responses. Nuclear factor kappaB/Rel (NFκB/Rel) transcription factors are ubiquitously
expressed signalling molecules, known to regulate the transcription of a large number of
genes involved in immune responses, including cytokines such as IL-1, IL-6, TNF-α and cell
surface molecules (MHC class I and II, B7. 2). In this study, we have compared the activation
of five members of the NF-κB family, p65, c-Rel, p50, RelB and p52, during DC maturation in …
responses. Nuclear factor kappaB/Rel (NFκB/Rel) transcription factors are ubiquitously
expressed signalling molecules, known to regulate the transcription of a large number of
genes involved in immune responses, including cytokines such as IL-1, IL-6, TNF-α and cell
surface molecules (MHC class I and II, B7. 2). In this study, we have compared the activation
of five members of the NF-κB family, p65, c-Rel, p50, RelB and p52, during DC maturation in …