Chromosomal abnormalities in cancer
S Fröhling, H Döhner - New England Journal of Medicine, 2008 - Mass Medical Soc
New England Journal of Medicine, 2008•Mass Medical Soc
This review gives an account of chromosomal aberrations in cancer cells. Such
abnormalities have typically been associated with hematologic cancers, but recent work has
shown a variety of chromosomal changes in solid tumors, including prostate cancer and non–
small-cell lung cancer. The authors point out that some of the chromosomal abnormalities
have revealed targets for cancer treatment, and others have clinical application in the
diagnosis of certain types of neoplasms and in the formulation of a prognosis.
abnormalities have typically been associated with hematologic cancers, but recent work has
shown a variety of chromosomal changes in solid tumors, including prostate cancer and non–
small-cell lung cancer. The authors point out that some of the chromosomal abnormalities
have revealed targets for cancer treatment, and others have clinical application in the
diagnosis of certain types of neoplasms and in the formulation of a prognosis.
This review gives an account of chromosomal aberrations in cancer cells. Such abnormalities have typically been associated with hematologic cancers, but recent work has shown a variety of chromosomal changes in solid tumors, including prostate cancer and non–small-cell lung cancer. The authors point out that some of the chromosomal abnormalities have revealed targets for cancer treatment, and others have clinical application in the diagnosis of certain types of neoplasms and in the formulation of a prognosis.
The New England Journal Of Medicine