Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies
W de Jager, BJ Prakken, JWJ Bijlsma, W Kuis… - Journal of …, 2005 - Elsevier
Cytokines, chemokines and soluble adhesion molecules interact in a complex network
within the immune system. Fingerprinting of these proteins may allow the use of these
proteins as biomarkers for identification of disease, disease subtyping and monitoring
therapeutic interventions. We developed a multiplex immunoassay (MIA) for the detection of
30 proteins in a variety of human body fluids such as plasma and synovial fuid (SF). The
measurement of these proteins is hampered by the presence of human (auto-) antibodies …
within the immune system. Fingerprinting of these proteins may allow the use of these
proteins as biomarkers for identification of disease, disease subtyping and monitoring
therapeutic interventions. We developed a multiplex immunoassay (MIA) for the detection of
30 proteins in a variety of human body fluids such as plasma and synovial fuid (SF). The
measurement of these proteins is hampered by the presence of human (auto-) antibodies …