Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules

CR Zimmermann, SM Johnson, GW Martens… - Infection and …, 1998 - Am Soc Microbiol
CR Zimmermann, SM Johnson, GW Martens, AG White, BL Zimmer, D Pappagianis
Infection and immunity, 1998Am Soc Microbiol
The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal
challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a
soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it
was accompanied by adjuvant, protected mice against lethal intranasal and intravenous
challenge with C. immitis.
Abstract
The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals withCoccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge withC. immitis.
American Society for Microbiology