[HTML][HTML] Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation
A Bernardo, AL Bergeron, CW Sun, P Guchhait… - Journal of Thrombosis …, 2004 - Elsevier
We examined the basis of the differences observed between different collagen preparations
in their ability to aggregate platelets and support their adhesion under flow. As in previous
studies, we found fibrillar collagen to be 10-fold more potent than acid-soluble collagen in
inducing platelet aggregation and found that acid-soluble collagen did not support the
adhesion of washed platelets under flow. Further, platelets in whole blood adhered to
surfaces coated with either fibrillar or acid-soluble collagen, but thrombi formed faster and …
in their ability to aggregate platelets and support their adhesion under flow. As in previous
studies, we found fibrillar collagen to be 10-fold more potent than acid-soluble collagen in
inducing platelet aggregation and found that acid-soluble collagen did not support the
adhesion of washed platelets under flow. Further, platelets in whole blood adhered to
surfaces coated with either fibrillar or acid-soluble collagen, but thrombi formed faster and …