Modulation of bronchial epithelial cells by IL-17
M Kawaguchi, F Kokubu, H Kuga, S Matsukura… - Journal of Allergy and …, 2001 - Elsevier
Background: The induction of epithelial cytokines/chemokines is crucial in the migration of
leukocytes, and its regulatory mechanisms remain incompletely defined. Objective: To
determine the role of IL-17, a CD4+ T cell–derived cytokine, in modulation of primary
bronchial epithelial cells, the expression of IL-6, IL-8, and intercellular adhesion molecule 1
(ICAM-1) and the potential involvement of mitogen-activated protein (MAP) kinases in IL-17–
mediated signaling were examined. Methods: The levels of gene expression and protein …
leukocytes, and its regulatory mechanisms remain incompletely defined. Objective: To
determine the role of IL-17, a CD4+ T cell–derived cytokine, in modulation of primary
bronchial epithelial cells, the expression of IL-6, IL-8, and intercellular adhesion molecule 1
(ICAM-1) and the potential involvement of mitogen-activated protein (MAP) kinases in IL-17–
mediated signaling were examined. Methods: The levels of gene expression and protein …