Exploiting the enhanced permeability and retention effect for tumor targeting
Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of
macromolecules is a key mechanism for solid tumor targeting, and considered a gold
standard for novel drug design. In this review, we discuss various endogenous factors that
can positively impact the EPR effect in tumor tissues. Further, we discuss ways to augment
the EPR effect by use of exogenous agents, as well as practical methods available in the
clinical setting. Some innovative examples developed by researchers to combat cancer by …
macromolecules is a key mechanism for solid tumor targeting, and considered a gold
standard for novel drug design. In this review, we discuss various endogenous factors that
can positively impact the EPR effect in tumor tissues. Further, we discuss ways to augment
the EPR effect by use of exogenous agents, as well as practical methods available in the
clinical setting. Some innovative examples developed by researchers to combat cancer by …
Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is a key mechanism for solid tumor targeting, and considered a gold standard for novel drug design. In this review, we discuss various endogenous factors that can positively impact the EPR effect in tumor tissues. Further, we discuss ways to augment the EPR effect by use of exogenous agents, as well as practical methods available in the clinical setting. Some innovative examples developed by researchers to combat cancer by the EPR mechanism are also discussed.
Elsevier
