[HTML][HTML] Mechanisms of FOXC2-and FOXD1-mediated regulation of the RIα subunit of cAMP-dependent protein kinase include release of transcriptional repression …
MK Dahle, LM Grønning, A Cederberg… - Journal of Biological …, 2002 - ASBMB
We have reported recently that mice overexpressing the forkhead/winged helix transcription
factorFOXC2 are lean and show increased responsiveness to insulin due to sensitization of
the β-adrenergic cAMP-PKA+ pathway and increased levels of the RIα subunit of cAMP-
dependent protein kinase (PKA)(Cederberg, A., Grønning, LM, Ahren, B., Taskén, K.,
Carlsson, P., and Enerbäck, S.(2001) Cell 106, 563–573). In this present study, we reveal
that FOXC2 and a related factor, FOXD1, specifically activate the 1b promoter of the RIα …
factorFOXC2 are lean and show increased responsiveness to insulin due to sensitization of
the β-adrenergic cAMP-PKA+ pathway and increased levels of the RIα subunit of cAMP-
dependent protein kinase (PKA)(Cederberg, A., Grønning, LM, Ahren, B., Taskén, K.,
Carlsson, P., and Enerbäck, S.(2001) Cell 106, 563–573). In this present study, we reveal
that FOXC2 and a related factor, FOXD1, specifically activate the 1b promoter of the RIα …