Ascending aortic dilatation associated with bicuspid aortic valve: pathophysiology, molecular biology, and clinical implications
TM Tadros, MD Klein, OM Shapira - Circulation, 2009 - Am Heart Assoc
TM Tadros, MD Klein, OM Shapira
Circulation, 2009•Am Heart AssocBAV aortas have histopathological findings similar to those of Marfan syndrome aortas, the
underlying genetic abnormality of Marfan syndrome—mutation in the FBN1 gene that
encodes fibrillin-133—is not found with BAV disease. Genomewide association studies may
reveal other genes involved with BAV disease.
underlying genetic abnormality of Marfan syndrome—mutation in the FBN1 gene that
encodes fibrillin-133—is not found with BAV disease. Genomewide association studies may
reveal other genes involved with BAV disease.
BAV aortas have histopathological findings similar to those of Marfan syndrome aortas, the underlying genetic abnormality of Marfan syndrome—mutation in the FBN1 gene that encodes fibrillin-133—is not found with BAV disease. Genomewide association studies may reveal other genes involved with BAV disease.
Am Heart Assoc