[HTML][HTML] Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response
KD Tardif, K Mori, RJ Kaufman, A Siddiqui - Journal of Biological Chemistry, 2004 - ASBMB
Hepatitis C virus (HCV) gene expression disrupts normal endoplasmic reticulum (ER)
functions and induces ER stress. ER stress results from the accumulation of unfolded or
misfolded proteins in the ER; cells can alleviate this stress by degrading or refolding these
proteins. The IRE1-XBP1 pathway directs both protein refolding and degradation in
response to ER stress. Like IRE1-XBP1, other branches of the ER stress response mediate
protein refolding. However, IRE1-XBP1 can also specifically activate protein degradation …
functions and induces ER stress. ER stress results from the accumulation of unfolded or
misfolded proteins in the ER; cells can alleviate this stress by degrading or refolding these
proteins. The IRE1-XBP1 pathway directs both protein refolding and degradation in
response to ER stress. Like IRE1-XBP1, other branches of the ER stress response mediate
protein refolding. However, IRE1-XBP1 can also specifically activate protein degradation …