The ADAM gene family: surface proteins with adhesion and protease activity
P Primakoff, DG Myles - Trends in Genetics, 2000 - cell.com
P Primakoff, DG Myles
Trends in Genetics, 2000•cell.comAn ADAM is a transmembrane protein that contains a disintegrin and metalloprotease
domain and, therefore, it potentially has both cell adhesion and protease activities.
Currently, the ADAM gene family has 29 members, although the function of most ADAM
gene products is unknown. We discuss the ADAM gene products with known functions that
act in a highly diverse set of biological processes, including fertilization, neurogenesis,
myogenesis, embryonic TGF-α release and the inflammatory response.
domain and, therefore, it potentially has both cell adhesion and protease activities.
Currently, the ADAM gene family has 29 members, although the function of most ADAM
gene products is unknown. We discuss the ADAM gene products with known functions that
act in a highly diverse set of biological processes, including fertilization, neurogenesis,
myogenesis, embryonic TGF-α release and the inflammatory response.
Abstract
An ADAM is a transmembrane protein that contains a disintegrin and metalloprotease domain and, therefore, it potentially has both cell adhesion and protease activities. Currently, the ADAM gene family has 29 members, although the function of most ADAM gene products is unknown. We discuss the ADAM gene products with known functions that act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-α release and the inflammatory response.
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