Sry and sex determination: how lazy can it be?
CA Canning, R Lovell-Badge - TRENDS in Genetics, 2002 - cell.com
TRENDS in Genetics, 2002•cell.com
Sry is at the top of the cascade of genetic activity leading to male development in mammals.
It does not have to work hard, however, to maintain its position. A quick burst of activity of this
Y-linked gene at the right time is all that is needed to trigger the downstream events. But
does SRY act on a single or several downstream targets? Recent data can be used to argue
that SRY has only one critical downstream target, Sox9. However, we should be a little
careful before jumping to this conclusion.
It does not have to work hard, however, to maintain its position. A quick burst of activity of this
Y-linked gene at the right time is all that is needed to trigger the downstream events. But
does SRY act on a single or several downstream targets? Recent data can be used to argue
that SRY has only one critical downstream target, Sox9. However, we should be a little
careful before jumping to this conclusion.
Abstract
Sry is at the top of the cascade of genetic activity leading to male development in mammals. It does not have to work hard, however, to maintain its position. A quick burst of activity of this Y-linked gene at the right time is all that is needed to trigger the downstream events. But does SRY act on a single or several downstream targets? Recent data can be used to argue that SRY has only one critical downstream target, Sox9. However, we should be a little careful before jumping to this conclusion.
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