[HTML][HTML] Notch and transforming growth factor-β (TGFβ) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation
Notch and transforming growth factor-β (TGFβ) play pivotal roles during vascular
development and the pathogenesis of vascular disease. The interaction of these two
pathways is not fully understood. The present study utilized primary human smooth muscle
cells (SMC) to examine molecular cross-talk between TGFβ1 and Notch signaling on
contractile gene expression. Activation of Notch signaling using Notch intracellular domain
or Jagged1 ligand induced smooth muscle α-actin (SM actin), smooth muscle myosin heavy …
development and the pathogenesis of vascular disease. The interaction of these two
pathways is not fully understood. The present study utilized primary human smooth muscle
cells (SMC) to examine molecular cross-talk between TGFβ1 and Notch signaling on
contractile gene expression. Activation of Notch signaling using Notch intracellular domain
or Jagged1 ligand induced smooth muscle α-actin (SM actin), smooth muscle myosin heavy …