Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
A Franke, T Balschun, TH Karlsen, J Hedderich… - Nature …, 2008 - nature.com
A Franke, T Balschun, TH Karlsen, J Hedderich, S May, T Lu, D Schuldt, S Nikolaus…
Nature genetics, 2008•nature.comFollowing up on recent genome-wide association studies (GWAS) of Crohn's disease, we
investigated 50 previously reported susceptibility loci in a German sample of individuals with
Crohn's disease (n= 1,850) or ulcerative colitis (n= 1,103) and healthy controls (n= 1,817).
Among these loci, we identified variants in 3p21. 31, NKX2-3 and CCNY as susceptibility
factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated
only with ulcerative colitis in our sample collection.
investigated 50 previously reported susceptibility loci in a German sample of individuals with
Crohn's disease (n= 1,850) or ulcerative colitis (n= 1,103) and healthy controls (n= 1,817).
Among these loci, we identified variants in 3p21. 31, NKX2-3 and CCNY as susceptibility
factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated
only with ulcerative colitis in our sample collection.
Abstract
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
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