Stimulation of intracellular Ca2+ levels in human neutrophils by soluble immune complexes: functional activation of FcγRIIIb during priming
F Watson, L Gasmi, SW Edwards - Journal of Biological Chemistry, 1997 - ASBMB
Soluble immune complexes bind to unprimed neutrophils and generate intracellular Ca 2+
transients but fail to activate the NADPH oxidase. Following priming of the neutrophils with
either tumor necrosis factor α or granulocyte-macrophage colony-stimulating factor,
stimulation of the cells with the soluble immune complexes leads to an enhanced Ca 2+
signal and significant secretion of reactive oxidants. The enhanced Ca 2+ signal observed in
primed neutrophils results from the influx of Ca 2+ from the external environment and is …
transients but fail to activate the NADPH oxidase. Following priming of the neutrophils with
either tumor necrosis factor α or granulocyte-macrophage colony-stimulating factor,
stimulation of the cells with the soluble immune complexes leads to an enhanced Ca 2+
signal and significant secretion of reactive oxidants. The enhanced Ca 2+ signal observed in
primed neutrophils results from the influx of Ca 2+ from the external environment and is …
