Induction and maintenance of CD8+ T cells specific for persistent viruses
EMM van Leeuwen, IJM ten Berge… - … between Innate and …, 2007 - Springer
EMM van Leeuwen, IJM ten Berge, RAW van Lier
Crossroads between Innate and Adaptive Immunity, 2007•SpringerThe development of immunological memory is a unique property of the adaptive immune
system. Until recently most studies on the induction of virus-specific memory CD8+ T cells
have been performed in mice models of acute infection. Based on these studies, certain
properties have been attributed to memory CD8+ T cells concerning their responsiveness to
antigenic stimulation and their ability to survive. However, many relevant human viruses are
persistent and reach a latency stage in which there is equilibrium between the virus and the …
system. Until recently most studies on the induction of virus-specific memory CD8+ T cells
have been performed in mice models of acute infection. Based on these studies, certain
properties have been attributed to memory CD8+ T cells concerning their responsiveness to
antigenic stimulation and their ability to survive. However, many relevant human viruses are
persistent and reach a latency stage in which there is equilibrium between the virus and the …
Abstract
The development of immunological memory is a unique property of the adaptive immune system. Until recently most studies on the induction of virus-specific memory CD8+ T cells have been performed in mice models of acute infection. Based on these studies, certain properties have been attributed to memory CD8+ T cells concerning their responsiveness to antigenic stimulation and their ability to survive. However, many relevant human viruses are persistent and reach a latency stage in which there is equilibrium between the virus and the host immune system.
Springer