[HTML][HTML] The duration of antigenic stimulation determines the fate of naive and effector T cells

G Iezzi, K Karjalainen, A Lanzavecchia - Immunity, 1998 - cell.com
G Iezzi, K Karjalainen, A Lanzavecchia
Immunity, 1998cell.com
It is known that T cells engage antigen-presenting cells (APCs) in a stable interaction that
results in sustained TCR signaling. We show here that the duration of this process is critical
in determining whether T cells will be activated or deleted. Whereas naive T cells require
approximately 20 hr of sustained signaling to be committed to proliferation, effector T cells
become committed after only 1 hr but die following activation if antigenic stimulation is
prolonged. Costimulation by anti-CD28 facilitates T cell activation by decreasing the time of …
Abstract
It is known that T cells engage antigen-presenting cells (APCs) in a stable interaction that results in sustained TCR signaling. We show here that the duration of this process is critical in determining whether T cells will be activated or deleted. Whereas naive T cells require approximately 20 hr of sustained signaling to be committed to proliferation, effector T cells become committed after only 1 hr but die following activation if antigenic stimulation is prolonged. Costimulation by anti-CD28 facilitates T cell activation by decreasing the time of commitment and by protecting T cells from death. These findings explain in quantitative terms the essential requirement for professional APCs in T cell priming and show that the duration of antigenic stimulation is the major factor determining the fate of naive and effector T cells.
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