Hepatocyte growth factor modulates matrix metalloproteinases and plasminogen activator/plasmin proteolytic pathways in progressive renal interstitial fibrosis
Evidence suggests that hepatocyte growth factor (HGF) ameliorates renal fibrosis in animal
models of chronic renal disease by promoting extracellular matrix catabolism. This study
examined the molecular mechanisms of HGF-induced alterations in matrix degradation both
in vitro and in vivo. In vitro, HGF increased the collagen catabolizing activity of human
proximal tubular epithelial cells (HKC) that were treated with TGF-β1. Increased collagen
catabolism was associated with enhanced activity of both matrix metalloproteinases (MMP) …
models of chronic renal disease by promoting extracellular matrix catabolism. This study
examined the molecular mechanisms of HGF-induced alterations in matrix degradation both
in vitro and in vivo. In vitro, HGF increased the collagen catabolizing activity of human
proximal tubular epithelial cells (HKC) that were treated with TGF-β1. Increased collagen
catabolism was associated with enhanced activity of both matrix metalloproteinases (MMP) …