Standardization of a neutralizing anti-vaccinia antibodies titration method: an essential step for titration of vaccinia immunoglobulins and smallpox vaccines evaluation
I Leparc-Goffart, B Poirier, D Garin, MH Tissier… - Journal of clinical …, 2005 - Elsevier
The possibility of mass population vaccination with smallpox vaccine implies the
development of anti-vaccinia immunoglobulins for the treatment of severe side effects
following vaccination. We have chosen to develop and validate the “gold standard
method”(plaque reduction neutralization assay) to titrate neutralizing anti-vaccinia
antibodies in two different French laboratories belonging to the Department of Defense
(CRSSA) and to the French Health Products Safety Agency (Afssaps). The results of …
development of anti-vaccinia immunoglobulins for the treatment of severe side effects
following vaccination. We have chosen to develop and validate the “gold standard
method”(plaque reduction neutralization assay) to titrate neutralizing anti-vaccinia
antibodies in two different French laboratories belonging to the Department of Defense
(CRSSA) and to the French Health Products Safety Agency (Afssaps). The results of …