The role of interferon-alpha in the treatment of chronic myeloid leukemia
LA Kujawski, M Talpaz - Cytokine & growth factor reviews, 2007 - Elsevier
Biological agents have long been used in the treatment of cancer, and interferon-alpha was
the first human cytokine to be widely studied in this setting. Chronic myeloid leukemia (CML)
is a hematopoietic stem cell disorder for which interferon-alpha has demonstrated
substantial activity. In the 1980s interferon-alpha became first-line therapy for patients with
chronic-phase CML, not eligible for allogeneic stem cell transplantation. Following the
discovery of the leukemic oncogene BCR/ABL and its causal association with CML, the …
the first human cytokine to be widely studied in this setting. Chronic myeloid leukemia (CML)
is a hematopoietic stem cell disorder for which interferon-alpha has demonstrated
substantial activity. In the 1980s interferon-alpha became first-line therapy for patients with
chronic-phase CML, not eligible for allogeneic stem cell transplantation. Following the
discovery of the leukemic oncogene BCR/ABL and its causal association with CML, the …