Polyovular follicles in the ovary of immature mice exposed prenatally to diethylstilbestrol
T Iguchi, N Takasugi - Anatomy and embryology, 1986 - Springer
T Iguchi, N Takasugi
Anatomy and embryology, 1986•SpringerPolyovular follicles (PF) occur in the ovary of 30-day-old offspring of ICR/JCL mice given 4
daily subcutaneous injections of 20–2,000 μg diethylstilbestrol (DES)/day from days 15 to 18
of gestation. PF containing 2–9 oocytes per follicle in the prenatally DES-exposed mice are
increased 33-to 112-fold as compared to controls. In 5-to 25-day-old offspring of mothers
given injections of 2,000 μg DES/day, PF are observed 17–65 times more frequent than in
controls.
daily subcutaneous injections of 20–2,000 μg diethylstilbestrol (DES)/day from days 15 to 18
of gestation. PF containing 2–9 oocytes per follicle in the prenatally DES-exposed mice are
increased 33-to 112-fold as compared to controls. In 5-to 25-day-old offspring of mothers
given injections of 2,000 μg DES/day, PF are observed 17–65 times more frequent than in
controls.
Summary
Polyovular follicles (PF) occur in the ovary of 30-day-old offspring of ICR/JCL mice given 4 daily subcutaneous injections of 20–2,000 μg diethylstilbestrol (DES)/day from days 15 to 18 of gestation. PF containing 2–9 oocytes per follicle in the prenatally DES-exposed mice are increased 33- to 112-fold as compared to controls. In 5- to 25-day-old offspring of mothers given injections of 2,000 μg DES/day, PF are observed 17–65 times more frequent than in controls.
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