[HTML][HTML] Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

H Malhi, SF Bronk, NW Werneburg, GJ Gores - Journal of Biological …, 2006 - ASBMB
Elevated serum free fatty acids (FFAs) and hepatocyte lipoapoptosis are features of non-
alcoholic fatty liver disease. However, the mechanism by which FFAs mediate lipoapoptosis
is unclear. Because JNK activation is pivotal in both the metabolic syndrome accompanying
non-alcoholic fatty liver disease and cellular apoptosis, we examined the role of JNK
activation in FFA-induced lipoapoptosis. Multiple hepatocyte cell lines and primary mouse
hepatocytes were treated in culture with monounsaturated fatty acids and saturated fatty …