[HTML][HTML] Inhibition of SUV39H1 methyltransferase activity by DBC1
Z Li, L Chen, N Kabra, C Wang, J Fang… - Journal of Biological …, 2009 - ASBMB
SUV39H1 is a histone H3K9-specific methyltransferase important for heterochromatin
formation, regulation of gene expression, and induction of senescence in premalignant cells.
SUV39H1 forms a complex with SirT1, and its activity is stimulated by SirT1 binding. Here
we present evidence that the product of the DBC1 (deleted in breast cancer 1) gene disrupts
the SUV39H1-SirT1 complex. Furthermore, DBC1 binds to the SUV39H1 catalytic domain
and inhibits its ability to methylate histone H3 in vitro and in vivo. Knockdown of endogenous …
formation, regulation of gene expression, and induction of senescence in premalignant cells.
SUV39H1 forms a complex with SirT1, and its activity is stimulated by SirT1 binding. Here
we present evidence that the product of the DBC1 (deleted in breast cancer 1) gene disrupts
the SUV39H1-SirT1 complex. Furthermore, DBC1 binds to the SUV39H1 catalytic domain
and inhibits its ability to methylate histone H3 in vitro and in vivo. Knockdown of endogenous …