[HTML][HTML] Deleted in breast cancer 1, a novel androgen receptor (AR) coactivator that promotes AR DNA-binding activity

J Fu, J Jiang, J Li, S Wang, G Shi, Q Feng… - Journal of biological …, 2009 - ASBMB
Androgen receptor (AR) plays a critical role in development and maintenance of male
reproductive functions and the etiology of prostate cancer. As a ligand-regulated
transcription factor, identification and characterization of AR coregulators are essential for
understanding the molecular mechanisms underlying its diverse biological functions. Here
we reported the identification of a novel AR coactivator, deleted in breast cancer 1 (DBC1),
through a biochemical approach. DBC1 interacts with AR in a ligand-stimulated manner and …