[HTML][HTML] Endogenous coactivator ARA70 interacts with estrogen receptor α (ERα) and modulates the functional ERα/androgen receptor interplay in MCF-7 cells
M Lanzino, F De Amicis, MJ McPhaul, S Marsico… - Journal of Biological …, 2005 - ASBMB
Overexpression of androgen receptor (AR) decreases estrogen receptor α (ERα)
transactivation, which plays a basic role in hormone-dependent breast cancer. This
transcriptional interference can be due to shared coactivators. Here we demonstrated that in
MCF-7 cells ARA70, an AR-specific coactivator, interacted with endogenous ERα,
increasing its transcriptional activity, and it was recruited to the pS2 gene promoter.
Moreover, a dominant negative ARA70 down-regulated ERα transcriptional activity as well …
transactivation, which plays a basic role in hormone-dependent breast cancer. This
transcriptional interference can be due to shared coactivators. Here we demonstrated that in
MCF-7 cells ARA70, an AR-specific coactivator, interacted with endogenous ERα,
increasing its transcriptional activity, and it was recruited to the pS2 gene promoter.
Moreover, a dominant negative ARA70 down-regulated ERα transcriptional activity as well …