[HTML][HTML] Activation of CaMKIIδC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis
W Zhu, AYH Woo, D Yang, H Cheng, MT Crow… - Journal of Biological …, 2007 - ASBMB
Ca 2+-calmodulin-dependent protein kinase II (CaMKII) is expressed in many mammalian
cells, with the δ isoform predominantly expressed in cardiomyocytes. Previous studies have
shown that inhibition of CaMKII protects cardiomyocytes against β 1-adrenergic receptor-
mediated apoptosis. However, it is unclear whether activation of CaMKII is sufficient to cause
cardiomyocyte apoptosis and whether CaMKII signaling is important in heart muscle cell
apoptosis mediated by other stimuli. Here, we specifically enhanced or suppressed CaMKII …
cells, with the δ isoform predominantly expressed in cardiomyocytes. Previous studies have
shown that inhibition of CaMKII protects cardiomyocytes against β 1-adrenergic receptor-
mediated apoptosis. However, it is unclear whether activation of CaMKII is sufficient to cause
cardiomyocyte apoptosis and whether CaMKII signaling is important in heart muscle cell
apoptosis mediated by other stimuli. Here, we specifically enhanced or suppressed CaMKII …