[HTML][HTML] The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
Recent studies have revealed new roles for NAD and its derivatives in transcriptional
regulation. The evolutionarily conserved Sir2 protein family requires NAD for its deacetylase
activity and regulates a variety of biological processes, such as stress response,
differentiation, metabolism, and aging. Despite its absolute requirement for NAD, the
regulation of Sir2 function by NAD biosynthesis pathways is poorly understood in mammals.
In this study, we determined the kinetics of the NAD biosynthesis mediated by nicotinamide …
regulation. The evolutionarily conserved Sir2 protein family requires NAD for its deacetylase
activity and regulates a variety of biological processes, such as stress response,
differentiation, metabolism, and aging. Despite its absolute requirement for NAD, the
regulation of Sir2 function by NAD biosynthesis pathways is poorly understood in mammals.
In this study, we determined the kinetics of the NAD biosynthesis mediated by nicotinamide …