[HTML][HTML] Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation

JA Encinar, GV Mallo, C Mizyrycki, L Giono… - Journal of Biological …, 2001 - ASBMB
We have studied the biochemical features, the conformational preferences in solution, and
the DNA binding properties of human p8 (hp8), a nucleoprotein whose expression is
affected during acute pancreatitis. Biochemical studies show that hp8 has properties of the
high mobility group proteins, HMG-I/Y. Structural studies have been carried out by using
circular dichroism (near-and far-ultraviolet), Fourier transform infrared, and NMR
spectroscopies. All the biophysical probes indicate that hp8 is monomeric (up to 1 mm …