Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS
PS Sapieha, L Duplan, N Uetani, S Joly… - Molecular and Cellular …, 2005 - Elsevier
Recently, receptor protein tyrosine phosphatase-σ (RPTPσ) has been shown to inhibit axon
regeneration in injured peripheral nerves. Unlike the peripheral nervous system (PNS),
central nervous system (CNS) neurons fail to regenerate their axons after injury or in
disease. In order to assess the role of RPTPσ in CNS regeneration, we used the
retinocollicular system of adult mice lacking RPTPσ to evaluate retinal ganglion cell (RGC)
axon regrowth after optic nerve lesion. Quantitative analysis demonstrated a significant …
regeneration in injured peripheral nerves. Unlike the peripheral nervous system (PNS),
central nervous system (CNS) neurons fail to regenerate their axons after injury or in
disease. In order to assess the role of RPTPσ in CNS regeneration, we used the
retinocollicular system of adult mice lacking RPTPσ to evaluate retinal ganglion cell (RGC)
axon regrowth after optic nerve lesion. Quantitative analysis demonstrated a significant …