A murine model of toluene diisocyanate–induced asthma can be treated with matrix metalloproteinase inhibitor
YC Lee, CH Song, HB Lee, JL Ohc, YK Rhee… - Journal of allergy and …, 2001 - Elsevier
Background: Toluene diisocyanate (TDI) is a leading cause of occupational asthma. TDI-
induced asthma is an inflammatory disease of the airways that is associated with airway
remodeling. However, there are little data available on the role of matrix metalloproteinases
(MMPs) in TDI-induced asthma. Objective: We evaluated whether MMP-9 participates in the
airway inflammation in TDI-induced asthma. An additional aim of the present study was to
determine whether MMP inhibitors could be effective therapeutic agents for TDI-induced …
induced asthma is an inflammatory disease of the airways that is associated with airway
remodeling. However, there are little data available on the role of matrix metalloproteinases
(MMPs) in TDI-induced asthma. Objective: We evaluated whether MMP-9 participates in the
airway inflammation in TDI-induced asthma. An additional aim of the present study was to
determine whether MMP inhibitors could be effective therapeutic agents for TDI-induced …