Epitope clustering in regions undergoing efficient proteasomal processing defines immunodominant CTL regions of a tumor antigen
D Valmori, F Lévy, E Godefroy, L Scotto… - Clinical …, 2007 - Elsevier
Identification of immunodominant CD8+ T cell responses to frequently expressed tumor
antigens across MHC class I polymorphism is essential for the implementation of cancer
immunotherapy. However, the key factors that determine immunodominance are not fully
understood. Because of its frequent expression in tumors and its spontaneous
immunogenicity, NY-ESO-1 is a prime target of cancer vaccines and an ideal model antigen
for elucidating the molecular basis of immunodominant tumor-specific CD8+ T cell …
antigens across MHC class I polymorphism is essential for the implementation of cancer
immunotherapy. However, the key factors that determine immunodominance are not fully
understood. Because of its frequent expression in tumors and its spontaneous
immunogenicity, NY-ESO-1 is a prime target of cancer vaccines and an ideal model antigen
for elucidating the molecular basis of immunodominant tumor-specific CD8+ T cell …