Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes
K Kozar, P Sicinski - Cell cycle, 2005 - Taylor & Francis
K Kozar, P Sicinski
Cell cycle, 2005•Taylor & FrancisD-type cyclins (cyclin D1, D2 and D3) and their associated cyclin-dependent kinases CDK4
and CDK6 were thought to represent important, perhaps essential components of the core
cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and
CDK6 reveal that these proteins are critically required for proliferation only in the selected
cell types. Intriguingly, several compartments can develop in the absence of cyclin D-
CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion.
and CDK6 were thought to represent important, perhaps essential components of the core
cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and
CDK6 reveal that these proteins are critically required for proliferation only in the selected
cell types. Intriguingly, several compartments can develop in the absence of cyclin D-
CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion.
D-type cyclins (cyclin D1, D2 and D3) and their associated cyclin-dependent kinases CDK4 and CDK6 were thought to represent important, perhaps essential components of the core cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and CDK6 reveal that these proteins are critically required for proliferation only in the selected cell types. Intriguingly, several compartments can develop in the absence of cyclin D-CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion.
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