Renal and bone marrow cells fuse after renal ischemic injury
L Li, P Truong, P Igarashi, F Lin - Journal of the American Society …, 2007 - journals.lww.com
After acute kidney injury, bone marrow cells contribute to renal repair by converting into
renal cells, but the mechanism of this conversion is not well understood. To determine
whether cell fusion between bone marrow cells and injured renal cells plays a role, we
subjected female mice expressing Cre recombinase in tubular epithelial cells to unilateral
renal ischemia-reperfusion injury, and subsequently transplanted male bone marrow cells
containing a loxP-flanked reporter gene. After 28 days, cell fusion was detected by polysomy …
renal cells, but the mechanism of this conversion is not well understood. To determine
whether cell fusion between bone marrow cells and injured renal cells plays a role, we
subjected female mice expressing Cre recombinase in tubular epithelial cells to unilateral
renal ischemia-reperfusion injury, and subsequently transplanted male bone marrow cells
containing a loxP-flanked reporter gene. After 28 days, cell fusion was detected by polysomy …
