Blockade of p38 Mitogen-Activated Protein Kinase and TGF-β1/Smad Signaling Pathways Rescues Bone Marrow–Derived Peritubular Capillary Endothelial Cells in …
J Li, JA Deane, NV Campanale… - Journal of the …, 2006 - journals.lww.com
The peritubular capillary (PTC) network is a component of the tubulointerstitium of the kidney
with important roles in renal function and hemodynamics. Bone marrow (BM)-derived cells
can contribute to repair of the renal PTC network after ischemic injury. However, the cell fate
and the regulation of renal BM-derived cell engraftment in comparison with somatic cells
during disease progression are unclear. This study characterized the time course and
regulation of PTC endothelial cell injury in adriamycin (ADR)-induced nephropathy in mice …
with important roles in renal function and hemodynamics. Bone marrow (BM)-derived cells
can contribute to repair of the renal PTC network after ischemic injury. However, the cell fate
and the regulation of renal BM-derived cell engraftment in comparison with somatic cells
during disease progression are unclear. This study characterized the time course and
regulation of PTC endothelial cell injury in adriamycin (ADR)-induced nephropathy in mice …
