Renal tubular regeneration by bone marrow—derived cells in a girl after bone marrow transplantation
M Nishida, H Kawakatsu, I Shiraishi, S Fujimoto… - American Journal of …, 2003 - Elsevier
M Nishida, H Kawakatsu, I Shiraishi, S Fujimoto, T Gotoh, Y Urata, T Ono, K Hamaoka
American Journal of Kidney Diseases, 2003•ElsevierRecent studies have indicated that bone marrow cells can contribute to regeneration of the
kidney in experimental models. However, renal regeneration by apparent bone marrow—
derived cells has not been shown previously in humans. The authors here report on a 7-year-
old girl who received whole bone marrow transplantation from a male donor, and the
contribution of bone marrow cells to the regeneration after renal damage was shown by in
situ hybridization for the Y chromosome on autopsy specimens of the kidney. This …
kidney in experimental models. However, renal regeneration by apparent bone marrow—
derived cells has not been shown previously in humans. The authors here report on a 7-year-
old girl who received whole bone marrow transplantation from a male donor, and the
contribution of bone marrow cells to the regeneration after renal damage was shown by in
situ hybridization for the Y chromosome on autopsy specimens of the kidney. This …
Recent studies have indicated that bone marrow cells can contribute to regeneration of the kidney in experimental models. However, renal regeneration by apparent bone marrow—derived cells has not been shown previously in humans. The authors here report on a 7-year-old girl who received whole bone marrow transplantation from a male donor, and the contribution of bone marrow cells to the regeneration after renal damage was shown by in situ hybridization for the Y chromosome on autopsy specimens of the kidney. This observation suggests the clinical potential of bone marrow cells as a therapeutic option for renal injury.
Elsevier
